diff --git a/docs/codeql/reusables/supported-frameworks.rst b/docs/codeql/reusables/supported-frameworks.rst
index 5ab3b605834..ebc17dd90cc 100644
--- a/docs/codeql/reusables/supported-frameworks.rst
+++ b/docs/codeql/reusables/supported-frameworks.rst
@@ -202,6 +202,7 @@ and the CodeQL library pack ``codeql/python-all`` (`changelog <https://github.co
    Flask-Admin, Web framework
    Tornado, Web framework
    Twisted, Web framework
+   Gradio, Web framework
    starlette, Asynchronous Server Gateway Interface (ASGI)
    ldap3, Lightweight Directory Access Protocol (LDAP)
    python-ldap, Lightweight Directory Access Protocol (LDAP)
diff --git a/python/ql/lib/semmle/python/Frameworks.qll b/python/ql/lib/semmle/python/Frameworks.qll
index a6288dadc11..83d78b57986 100644
--- a/python/ql/lib/semmle/python/Frameworks.qll
+++ b/python/ql/lib/semmle/python/Frameworks.qll
@@ -29,6 +29,7 @@ private import semmle.python.frameworks.FastApi
 private import semmle.python.frameworks.Flask
 private import semmle.python.frameworks.FlaskAdmin
 private import semmle.python.frameworks.FlaskSqlAlchemy
+private import semmle.python.frameworks.Gradio
 private import semmle.python.frameworks.Httpx
 private import semmle.python.frameworks.Idna
 private import semmle.python.frameworks.Invoke
diff --git a/python/ql/lib/semmle/python/frameworks/Gradio.qll b/python/ql/lib/semmle/python/frameworks/Gradio.qll
new file mode 100644
index 00000000000..ddf82487ce5
--- /dev/null
+++ b/python/ql/lib/semmle/python/frameworks/Gradio.qll
@@ -0,0 +1,137 @@
+/**
+ * Provides classes modeling security-relevant aspects of the `gradio` PyPI package.
+ * See https://pypi.org/project/gradio/.
+ */
+
+import python
+import semmle.python.dataflow.new.RemoteFlowSources
+import semmle.python.dataflow.new.TaintTracking
+import semmle.python.ApiGraphs
+
+
+module Gradio {
+  /**
+   * Event handlers in Gradio, which are sources of untrusted data.
+   */
+
+  class GradioInput extends API::CallNode {
+      GradioInput() { this = API::moduleImport("gradio")
+      .getMember([
+      "Button", "Textbox", "UploadButton", "Slider",
+      "JSON", "HTML", "Markdown", "File",
+      "AnnotatedImage", "Audio", "BarPlot", "Chatbot", "Checkbox",
+      "CheckboxGroup", "ClearButton", "Code", "ColorPicker", "Dataframe",
+      "Dataset", "DownloadButton", "Dropdown", "DuplicateButton", "FileExplorer",
+      "Gallery", "HighlightedText", "Image", "ImageEditor", "Label", "LinePlot",
+      "LoginButton", "LogoutButton", "Model3D", "Number", "ParamViewer",
+      "Plot", "Radio", "ScatterPlot", "SimpleImage", "State", "Video"])
+      .getReturn()
+      .getMember([
+      "change", "input", "click", "submit",
+      "edit", "clear", "play", "pause", "stop", "end", "start_recording",
+      "pause_recording", "stop_recording", "focus", "blur",
+      "upload", "release", "select", "stream", "like", "load",
+      "like", "key_up",])
+      .getACall()
+      }
+
+    }
+
+    class GradioInterface extends API::CallNode {
+      GradioInterface() { this = API::moduleImport("gradio").getMember(["Interface", "ChatInterface"]).getACall() }
+    }
+
+  /**
+   * Track `inputs` parameters in Gradio event handlers, that are lists, back to source, f.ex. `gr.Textbox(...)`. Handle keyword and positional parameters.
+   */
+  class GradioInputList extends RemoteFlowSource::Range {
+    GradioInputList() {
+    exists(API::CallNode call |
+    (call instanceof GradioInput
+        or
+        call instanceof GradioInterface)
+        and
+        // limit only to lists of parameters given to `inputs`.
+        ((call.getKeywordParameter("inputs").asSink().asCfgNode() instanceof ListNode
+            or
+            call.getParameter(1).asSink().asCfgNode() instanceof ListNode)
+        and
+        (this = call.getKeywordParameter("inputs").getASuccessor().getAValueReachingSink()
+        or
+        this = call.getParameter(1).getASuccessor().getAValueReachingSink()))
+    )
+    }
+    override string getSourceType() { result = "Gradio untrusted input" }
+
+
+  }
+
+  /**
+   * Track `inputs` parameters in Gradio event handlers, that are not lists. Handle keyword and positional parameters.
+   */
+  class GradioInputParameter extends RemoteFlowSource::Range {
+    GradioInputParameter() {
+    exists(API::CallNode call |
+      (call instanceof GradioInput
+      or
+      call instanceof GradioInterface)
+
+      and
+      (this = call.getKeywordParameter("fn").getParameter(_).asSource()
+      or
+      this = call.getParameter(0).getParameter(_).asSource())
+
+      and
+      // exclude lists of parameters given to `inputs`
+      not call.getKeywordParameter("inputs").asSink().asCfgNode() instanceof ListNode
+      and
+      not call.getParameter(1).asSink().asCfgNode() instanceof ListNode
+      )
+    }
+  override string getSourceType() { result = "Gradio untrusted input" }
+ }
+
+  /**
+   * Track `inputs` parameters in Gradio decorators to event handlers.
+   */
+ class GradioInputDecorator extends RemoteFlowSource::Range {
+    GradioInputDecorator() {
+      exists(API::CallNode call |
+        (call instanceof GradioInput or call instanceof GradioInterface)
+        and
+        this = call.getReturn().getACall().getParameter(0).getParameter(_).asSource()
+      )
+    }
+  override string getSourceType() { result = "Gradio untrusted input" }
+ }
+
+  /**
+   * Extra taint propagation for tracking `inputs` parameters in Gradio event handlers, that are lists.
+   */
+  private class ListTaintStep extends TaintTracking::AdditionalTaintStep {
+    override predicate step(DataFlow::Node nodeFrom, DataFlow::Node nodeTo) {
+      exists(API::CallNode node |
+        (node instanceof GradioInput
+        or
+        node instanceof GradioInterface)
+        and
+        // handle cases where there are multiple arguments passed as a list to `inputs`
+        ((
+          (node.getKeywordParameter("inputs").asSink().asCfgNode() instanceof ListNode
+          or
+          node.getParameter(1).asSink().asCfgNode() instanceof ListNode)
+        and
+        exists(int i |
+          (nodeTo = node.getParameter(0).getParameter(i).asSource()
+          or
+          nodeTo = node.getKeywordParameter("fn").getParameter(i).asSource())
+          and
+          (nodeFrom.asCfgNode() = node.getKeywordParameter("inputs").asSink().asCfgNode().(ListNode).getElement(i)
+          or
+          nodeFrom.asCfgNode() = node.getParameter(1).asSink().asCfgNode().(ListNode).getElement(i))))
+        )
+      )
+    }
+  }
+
+}
diff --git a/python/ql/test/library-tests/frameworks/gradio/source_test.py b/python/ql/test/library-tests/frameworks/gradio/source_test.py
new file mode 100644
index 00000000000..2b26a5f3ac6
--- /dev/null
+++ b/python/ql/test/library-tests/frameworks/gradio/source_test.py
@@ -0,0 +1,29 @@
+import gradio as gr
+
+
+with gr.Blocks() as demo:
+    name = gr.Textbox(label="Name")
+    output = gr.Textbox(label="Output Box")
+    greet_btn = gr.Button("Hello")
+
+	# decorator
+    @greet_btn.click(inputs=name, outputs=output)
+    def greet(name):
+        return "Hello " + name + "!"
+
+    # `click` event handler with keyword arguments
+    def greet1(name):
+        return "Hello " + name + "!"
+
+    greet1_btn = gr.Button("Hello")
+    greet1_btn.click(fn=greet1, inputs=name, outputs=output, api_name="greet")
+
+    # `click` event handler with positional arguments
+    def greet2(name):
+        return "Hello " + name + "!"
+
+    greet2_btn = gr.Button("Hello")
+    greet2_btn.click(fn=greet2, inputs=name, outputs=output, api_name="greet")
+
+
+demo.launch()
diff --git a/python/ql/test/library-tests/frameworks/gradio/taint_step_test.py b/python/ql/test/library-tests/frameworks/gradio/taint_step_test.py
new file mode 100644
index 00000000000..497520b18ec
--- /dev/null
+++ b/python/ql/test/library-tests/frameworks/gradio/taint_step_test.py
@@ -0,0 +1,22 @@
+import gradio as gr
+import os
+
+with gr.Blocks() as demo:
+    path = gr.Textbox(label="Path")
+    file = gr.Textbox(label="File")
+    output = gr.Textbox(label="Output Box")
+
+
+	# path injection sink
+    def fileread(path, file):
+        filepath = os.path.join(path, file)
+        with open(filepath, "r") as f:
+                return f.read()
+
+
+    # `click` event handler with `inputs` containing a list
+    greet1_btn = gr.Button("Path for the file to display")
+    greet1_btn.click(fn=fileread, inputs=[path,file], outputs=output, api_name="fileread")
+
+
+demo.launch()