diff --git a/python/ql/lib/semmle/python/Frameworks.qll b/python/ql/lib/semmle/python/Frameworks.qll
index f8298ffc7b7..569f7981e9d 100644
--- a/python/ql/lib/semmle/python/Frameworks.qll
+++ b/python/ql/lib/semmle/python/Frameworks.qll
@@ -34,6 +34,7 @@ private import semmle.python.frameworks.Idna
 private import semmle.python.frameworks.Invoke
 private import semmle.python.frameworks.Jmespath
 private import semmle.python.frameworks.Joblib
+private import semmle.python.frameworks.JsonPickle
 private import semmle.python.frameworks.Ldap
 private import semmle.python.frameworks.Ldap3
 private import semmle.python.frameworks.Libtaxii
@@ -48,6 +49,7 @@ private import semmle.python.frameworks.Oracledb
 private import semmle.python.frameworks.Pandas
 private import semmle.python.frameworks.Paramiko
 private import semmle.python.frameworks.Peewee
+private import semmle.python.frameworks.Pexpect
 private import semmle.python.frameworks.Phoenixdb
 private import semmle.python.frameworks.Psycopg
 private import semmle.python.frameworks.Psycopg2
diff --git a/python/ql/lib/semmle/python/frameworks/JsonPickle.qll b/python/ql/lib/semmle/python/frameworks/JsonPickle.qll
new file mode 100644
index 00000000000..1c1d0c1f54f
--- /dev/null
+++ b/python/ql/lib/semmle/python/frameworks/JsonPickle.qll
@@ -0,0 +1,32 @@
+/**
+ * Provides classes modeling security-relevant aspects of the `jsonpickle` PyPI package.
+ * See https://pypi.org/project/jsonpickle/.
+ */
+
+private import python
+private import semmle.python.dataflow.new.DataFlow
+private import semmle.python.dataflow.new.RemoteFlowSources
+private import semmle.python.Concepts
+private import semmle.python.ApiGraphs
+
+/**
+ * Provides models for the `jsonpickle` PyPI package.
+ * See https://pypi.org/project/jsonpickle/.
+ */
+private module Jsonpickle {
+  /**
+   * A Call to `jsonpickle.decode`.
+   * See https://jsonpickle.readthedocs.io/en/latest/api.html#jsonpickle.decode
+   */
+  private class JsonpickleDecode extends Decoding::Range, API::CallNode {
+    JsonpickleDecode() { this = API::moduleImport("jsonpickle").getMember("decode").getACall() }
+
+    override predicate mayExecuteInput() { any() }
+
+    override DataFlow::Node getAnInput() { result = this.getParameter(0, "string").asSink() }
+
+    override DataFlow::Node getOutput() { result = this }
+
+    override string getFormat() { result = "pickle" }
+  }
+}
diff --git a/python/ql/lib/semmle/python/frameworks/Paramiko.qll b/python/ql/lib/semmle/python/frameworks/Paramiko.qll
index e41d4b5ad55..2599271cc0c 100644
--- a/python/ql/lib/semmle/python/frameworks/Paramiko.qll
+++ b/python/ql/lib/semmle/python/frameworks/Paramiko.qll
@@ -14,7 +14,7 @@ private import semmle.python.ApiGraphs
  * See https://pypi.org/project/paramiko/.
  */
 private module Paramiko {
-  /*
+  /**
    * The first argument of `paramiko.ProxyCommand`.
    *
    * the `paramiko.ProxyCommand` is equivalent of `ssh -o ProxyCommand="CMD"`
@@ -22,7 +22,6 @@ private module Paramiko {
    *
    * See https://paramiko.pydata.org/docs/reference/api/paramiko.eval.html
    */
-
   class ParamikoProxyCommand extends SystemCommandExecution::Range, API::CallNode {
     ParamikoProxyCommand() {
       this = API::moduleImport("paramiko").getMember("ProxyCommand").getACall()
diff --git a/python/ql/lib/semmle/python/frameworks/Pexpect.qll b/python/ql/lib/semmle/python/frameworks/Pexpect.qll
new file mode 100644
index 00000000000..768bc2c3de1
--- /dev/null
+++ b/python/ql/lib/semmle/python/frameworks/Pexpect.qll
@@ -0,0 +1,46 @@
+/**
+ * Provides classes modeling security-relevant aspects of the `pexpect` PyPI package.
+ * See https://pypi.org/project/pexpect/.
+ */
+
+private import python
+private import semmle.python.dataflow.new.DataFlow
+private import semmle.python.dataflow.new.RemoteFlowSources
+private import semmle.python.Concepts
+private import semmle.python.ApiGraphs
+
+/**
+ * Provides models for the `pexpect` PyPI package.
+ * See https://pypi.org/project/pexpect/.
+ */
+private module Pexpect {
+  /**
+   * The calls to `pexpect.*` functions that execute commands
+   * See https://pexpect.readthedocs.io/en/stable/api/pexpect.html#pexpect.spawn
+   * See https://pexpect.readthedocs.io/en/stable/api/pexpect.html#pexpect.run
+   */
+  class PexpectCommandExec extends SystemCommandExecution::Range, API::CallNode {
+    PexpectCommandExec() {
+      this = API::moduleImport("pexpect").getMember(["run", "runu", "spawn", "spawnu"]).getACall()
+    }
+
+    override DataFlow::Node getCommand() { result = this.getParameter(0, "command").asSink() }
+
+    override predicate isShellInterpreted(DataFlow::Node arg) { none() }
+  }
+
+  /**
+   * A call to `pexpect.popen_spawn.PopenSpawn`
+   * See https://pexpect.readthedocs.io/en/stable/api/popen_spawn.html#pexpect.popen_spawn.PopenSpawn
+   */
+  class PexpectPopenSpawn extends SystemCommandExecution::Range, API::CallNode {
+    PexpectPopenSpawn() {
+      this =
+        API::moduleImport("pexpect").getMember("popen_spawn").getMember("PopenSpawn").getACall()
+    }
+
+    override DataFlow::Node getCommand() { result = this.getParameter(0, "cmd").asSink() }
+
+    override predicate isShellInterpreted(DataFlow::Node arg) { none() }
+  }
+}
diff --git a/python/ql/src/experimental/semmle/python/Frameworks.qll b/python/ql/src/experimental/semmle/python/Frameworks.qll
index 45ef3cf96b4..1d8fe10e911 100644
--- a/python/ql/src/experimental/semmle/python/Frameworks.qll
+++ b/python/ql/src/experimental/semmle/python/Frameworks.qll
@@ -10,6 +10,7 @@ private import experimental.semmle.python.frameworks.Werkzeug
 private import experimental.semmle.python.frameworks.LDAP
 private import experimental.semmle.python.frameworks.Netmiko
 private import experimental.semmle.python.frameworks.Paramiko
+private import experimental.semmle.python.frameworks.Pexpect
 private import experimental.semmle.python.frameworks.Scrapli
 private import experimental.semmle.python.frameworks.JWT
 private import experimental.semmle.python.frameworks.Csv
diff --git a/python/ql/src/experimental/semmle/python/frameworks/Pexpect.qll b/python/ql/src/experimental/semmle/python/frameworks/Pexpect.qll
new file mode 100644
index 00000000000..86459d47c3d
--- /dev/null
+++ b/python/ql/src/experimental/semmle/python/frameworks/Pexpect.qll
@@ -0,0 +1,34 @@
+/**
+ * Provides classes modeling security-relevant aspects of the `pexpect` PyPI package.
+ * See https://pypi.org/project/pexpect/.
+ */
+
+private import python
+private import semmle.python.dataflow.new.DataFlow
+private import semmle.python.dataflow.new.RemoteFlowSources
+private import semmle.python.ApiGraphs
+import experimental.semmle.python.Concepts
+
+/**
+ * Provides models for the `pexpect` PyPI package.
+ * See https://pypi.org/project/pexpect/.
+ */
+private module Pexpect {
+  /**
+   * The calls to `pexpect.pxssh.pxssh` functions that execute commands
+   * See https://pexpect.readthedocs.io/en/stable/api/pxssh.html
+   */
+  class PexpectCommandExec extends SecondaryCommandInjection {
+    PexpectCommandExec() {
+      this =
+        API::moduleImport("pexpect")
+            .getMember("pxssh")
+            .getMember("pxssh")
+            .getReturn()
+            .getMember(["send", "sendline"])
+            .getACall()
+            .getParameter(0, "s")
+            .asSink()
+    }
+  }
+}
diff --git a/python/ql/test/experimental/query-tests/Security/CWE-074-SecondaryServerCmdInjection/Pexpect.py b/python/ql/test/experimental/query-tests/Security/CWE-074-SecondaryServerCmdInjection/Pexpect.py
new file mode 100644
index 00000000000..c3ee7420e19
--- /dev/null
+++ b/python/ql/test/experimental/query-tests/Security/CWE-074-SecondaryServerCmdInjection/Pexpect.py
@@ -0,0 +1,21 @@
+#!/usr/bin/env python
+
+from fastapi import FastAPI
+from pexpect import pxssh
+
+ssh = pxssh.pxssh()
+hostname = "localhost"
+username = "username"
+password = "password"
+ssh.login(hostname, username, password)
+
+app = FastAPI()
+
+@app.get("/bad1")
+async def bad1(cmd: str):
+    ssh.send(cmd)  # $ result=BAD getSecondaryCommand=cmd
+    ssh.prompt()
+    ssh.sendline(cmd)  # $ result=BAD getSecondaryCommand=cmd
+    ssh.prompt()
+    ssh.logout()
+    return {"success": stdout}
\ No newline at end of file
diff --git a/python/ql/test/library-tests/frameworks/jsonpickle/ConceptsTest.expected b/python/ql/test/library-tests/frameworks/jsonpickle/ConceptsTest.expected
new file mode 100644
index 00000000000..8ec8033d086
--- /dev/null
+++ b/python/ql/test/library-tests/frameworks/jsonpickle/ConceptsTest.expected
@@ -0,0 +1,2 @@
+testFailures
+failures
diff --git a/python/ql/test/library-tests/frameworks/jsonpickle/ConceptsTest.ql b/python/ql/test/library-tests/frameworks/jsonpickle/ConceptsTest.ql
new file mode 100644
index 00000000000..b557a0bccb6
--- /dev/null
+++ b/python/ql/test/library-tests/frameworks/jsonpickle/ConceptsTest.ql
@@ -0,0 +1,2 @@
+import python
+import experimental.meta.ConceptsTest
diff --git a/python/ql/test/library-tests/frameworks/jsonpickle/Decode.py b/python/ql/test/library-tests/frameworks/jsonpickle/Decode.py
new file mode 100644
index 00000000000..478e823a559
--- /dev/null
+++ b/python/ql/test/library-tests/frameworks/jsonpickle/Decode.py
@@ -0,0 +1,15 @@
+import os
+
+import jsonpickle
+
+
+class Thing(object):
+    def __reduce__(self):
+        return os.system, ("curl 127.0.0.1:1234",)
+
+
+obj = Thing()
+
+pickledObj = jsonpickle.encode(obj)
+objUnPickled = jsonpickle.decode(pickledObj, safe=True)  # $ decodeInput=pickledObj decodeOutput=jsonpickle.decode(..) decodeFormat=pickle decodeMayExecuteInput
+print(objUnPickled.name)
diff --git a/python/ql/test/library-tests/frameworks/pexpect/ConceptsTest.expected b/python/ql/test/library-tests/frameworks/pexpect/ConceptsTest.expected
new file mode 100644
index 00000000000..8ec8033d086
--- /dev/null
+++ b/python/ql/test/library-tests/frameworks/pexpect/ConceptsTest.expected
@@ -0,0 +1,2 @@
+testFailures
+failures
diff --git a/python/ql/test/library-tests/frameworks/pexpect/ConceptsTest.ql b/python/ql/test/library-tests/frameworks/pexpect/ConceptsTest.ql
new file mode 100644
index 00000000000..b557a0bccb6
--- /dev/null
+++ b/python/ql/test/library-tests/frameworks/pexpect/ConceptsTest.ql
@@ -0,0 +1,2 @@
+import python
+import experimental.meta.ConceptsTest
diff --git a/python/ql/test/library-tests/frameworks/pexpect/ExecCmd.py b/python/ql/test/library-tests/frameworks/pexpect/ExecCmd.py
new file mode 100644
index 00000000000..5f8c0886909
--- /dev/null
+++ b/python/ql/test/library-tests/frameworks/pexpect/ExecCmd.py
@@ -0,0 +1,9 @@
+import pexpect
+from pexpect import popen_spawn
+
+cmd = "ls -la"
+result = pexpect.run(cmd) # $ getCommand=cmd
+result = pexpect.runu(cmd) # $ getCommand=cmd
+result = pexpect.spawn(cmd) # $ getCommand=cmd
+result = pexpect.spawnu(cmd) # $ getCommand=cmd
+result = popen_spawn.PopenSpawn(cmd) # $ getCommand=cmd
\ No newline at end of file