diff --git a/python/ql/lib/semmle/python/frameworks/Lxml.qll b/python/ql/lib/semmle/python/frameworks/Lxml.qll
index 60cc850fd34..821fc6bac80 100644
--- a/python/ql/lib/semmle/python/frameworks/Lxml.qll
+++ b/python/ql/lib/semmle/python/frameworks/Lxml.qll
@@ -274,4 +274,34 @@ private module Lxml {
       result = this
     }
   }
+
+  /**
+   * A call to `lxml.etree.iterparse`
+   *
+   * See
+   * - https://lxml.de/apidoc/lxml.etree.html?highlight=parseids#lxml.etree.iterparse
+   */
+  private class LXMLIterparseCall extends DataFlow::CallCfgNode, XML::XMLParsing::Range {
+    LXMLIterparseCall() {
+      this = API::moduleImport("lxml").getMember("etree").getMember("iterparse").getACall()
+    }
+
+    override DataFlow::Node getAnInput() { result in [this.getArg(0), this.getArgByName("source")] }
+
+    override predicate vulnerableTo(XML::XMLParsingVulnerabilityKind kind) {
+      // note that there is no `resolve_entities` argument, so it's not possible to turn off XXE :O
+      kind.isXxe()
+      or
+      (kind.isBillionLaughs() or kind.isQuadraticBlowup()) and
+      this.getArgByName("huge_tree").getALocalSource().asExpr() = any(True t)
+      or
+      kind.isDtdRetrieval() and
+      this.getArgByName("load_dtd").getALocalSource().asExpr() = any(True t) and
+      this.getArgByName("no_network").getALocalSource().asExpr() = any(False t)
+    }
+
+    override predicate mayExecuteInput() { none() }
+
+    override DataFlow::Node getOutput() { result = this }
+  }
 }
diff --git a/python/ql/test/library-tests/frameworks/lxml/parsing.py b/python/ql/test/library-tests/frameworks/lxml/parsing.py
index e69a68a6ad2..5abd626caf4 100644
--- a/python/ql/test/library-tests/frameworks/lxml/parsing.py
+++ b/python/ql/test/library-tests/frameworks/lxml/parsing.py
@@ -16,11 +16,15 @@ lxml.etree.XML(text=x) # $ decodeFormat=XML decodeInput=x xmlVuln='XXE' decodeOu
 lxml.etree.XMLID(x) # $ decodeFormat=XML decodeInput=x xmlVuln='XXE' decodeOutput=lxml.etree.XMLID(..)
 lxml.etree.XMLID(text=x) # $ decodeFormat=XML decodeInput=x xmlVuln='XXE' decodeOutput=lxml.etree.XMLID(..)
 
-lxml.etree.parse(StringIO(x)) # $ decodeFormat=XML decodeInput=StringIO(..) xmlVuln='XXE' decodeOutput=lxml.etree.parse(..)
-lxml.etree.parse(source=StringIO(x)) # $ decodeFormat=XML decodeInput=StringIO(..) xmlVuln='XXE' decodeOutput=lxml.etree.parse(..)
+xml_file = 'xml_file'
+lxml.etree.parse(xml_file) # $ decodeFormat=XML decodeInput=xml_file xmlVuln='XXE' decodeOutput=lxml.etree.parse(..)
+lxml.etree.parse(source=xml_file) # $ decodeFormat=XML decodeInput=xml_file xmlVuln='XXE' decodeOutput=lxml.etree.parse(..)
 
-lxml.etree.parseid(StringIO(x)) # $ decodeFormat=XML decodeInput=StringIO(..) xmlVuln='XXE' decodeOutput=lxml.etree.parseid(..)
-lxml.etree.parseid(source=StringIO(x)) # $ decodeFormat=XML decodeInput=StringIO(..) xmlVuln='XXE' decodeOutput=lxml.etree.parseid(..)
+lxml.etree.parseid(xml_file) # $ decodeFormat=XML decodeInput=xml_file xmlVuln='XXE' decodeOutput=lxml.etree.parseid(..)
+lxml.etree.parseid(source=xml_file) # $ decodeFormat=XML decodeInput=xml_file xmlVuln='XXE' decodeOutput=lxml.etree.parseid(..)
+
+lxml.etree.iterparse(xml_file) # $ decodeFormat=XML decodeInput=xml_file xmlVuln='XXE' decodeOutput=lxml.etree.iterparse(..)
+lxml.etree.iterparse(source=xml_file) # $ decodeFormat=XML decodeInput=xml_file xmlVuln='XXE' decodeOutput=lxml.etree.iterparse(..)
 
 # With default parsers (nothing changed)
 parser = lxml.etree.XMLParser()
@@ -55,3 +59,9 @@ lxml.etree.fromstring(x, parser=parser) # $ decodeFormat=XML decodeInput=x decod
 # DTD retrival vuln (also XXE)
 parser = lxml.etree.XMLParser(load_dtd=True, no_network=False)
 lxml.etree.fromstring(x, parser=parser) # $ decodeFormat=XML decodeInput=x xmlVuln='DTD retrieval' xmlVuln='XXE' decodeOutput=lxml.etree.fromstring(..)
+
+# iterparse configurations ... this doesn't use a parser argument but takes MOST (!) of
+# the normal XMLParser arguments. Specifically, it doesn't allow disabling XXE :O
+
+lxml.etree.iterparse(xml_file, huge_tree=True) # $ decodeFormat=XML decodeInput=xml_file xmlVuln='Billion Laughs' xmlVuln='Quadratic Blowup' xmlVuln='XXE' decodeOutput=lxml.etree.iterparse(..)
+lxml.etree.iterparse(xml_file, load_dtd=True, no_network=False) # $ decodeFormat=XML decodeInput=xml_file xmlVuln='DTD retrieval' xmlVuln='XXE' decodeOutput=lxml.etree.iterparse(..)